Growth Hormone
FDA Approved
Evidence: Moderate

Sermorelin

Also known as: GHRH 1-29, GRF 1-29

Overview
Growth hormone deficiency and anti-aging

Sermorelin is a bioidentical synthetic version of growth hormone releasing hormone (GHRH) consisting of the first 29 amino acids of the full 44-amino acid GHRH molecule. It is FDA-approved for diagnostic testing of GH secretion but is widely used off-label for anti-aging and growth hormone optimization. Unlike direct HGH replacement, sermorelin stimulates the body's own production of growth hormone.

Mechanism of Action

Bioidentical analog of growth hormone releasing hormone (GHRH) that stimulates natural GH production

Dosage Information
ParameterDetail
AdministrationSubcutaneous injection
Typical Dose200-500mcg daily before bed
FrequencyDaily
Side Effects
Reported adverse effects from clinical data and post-market surveillance

Common Side Effects

Injection site reactions
Flushing
Headache
Dizziness
Hyperactivity

Serious Side Effects

Antibody formation
Altered glucose metabolism
!Contraindications
Do not use this peptide if any of the following apply
  • Active cancer
  • Pituitary tumor
  • Pregnancy
  • Children with closed growth plates
Clinical Evidence

Evidence Quality

Moderate

Clinical Trial Phase

Approved (post-market)

Cost Comparison
Estimated monthly costs compared to similar peptides
PeptideMonthly CostFDA Status
Sermorelin$150 - $350/mo
FDA Approved
MK-677$50 - $100/mo
Phase 2
CJC-1295$35 - $70/mo
Not submitted
Ipamorelin$35 - $70/mo
Not submitted
GHRP-6$35 - $70/mo
Not submitted
Compare Sermorelin
See how Sermorelin stacks up against similar peptides

Medical Disclaimer

The information provided on this page is for educational and informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting, stopping, or modifying any peptide therapy or medication. PeptideVS does not endorse, recommend, or promote the use of any specific peptide for medical treatment. Clinical data cited may be from ongoing trials and is subject to change. Individual results may vary.