Sermorelin vs Tesamorelin
A comprehensive, data-driven comparison of Sermorelin (GHRH 1-29) and Tesamorelin (Egrifta). Compare efficacy, side effects, costs, FDA approval status, and clinical evidence to make an informed decision.
Side-by-Side Comparison
| Property | Sermorelin GHRH 1-29, GRF 1-29 | Tesamorelin Egrifta, TH9507 |
|---|---|---|
| FDA Status | FDA Approved | FDA Approved |
| Category | Growth Hormone | Growth Hormone |
| Primary Use | Growth hormone deficiency and anti-aging | HIV-associated lipodystrophy |
| Weight Loss % | N/A | N/A |
| Monthly Cost | $150 - $350/mo | $500 - $1,200/mo |
| Administration | Subcutaneous injection | Subcutaneous injection |
| Typical Dose | 200-500mcg daily before bed | 2mg daily |
| Frequency | Daily | Daily |
| Mechanism | Bioidentical analog of growth hormone releasing hormone (GHRH) that stimulates natural GH production | Synthetic GHRH analog that reduces visceral adipose tissue by stimulating growth hormone production |
| Common Side Effects |
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| Serious Side Effects |
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| Evidence Quality | Moderate | High |
| Clinical Trial Phase | Approved | Approved |
Key Differences
- 1Sermorelin is generally more affordable ($150 - $350/mo) compared to Tesamorelin ($500 - $1,200/mo).
- 2Tesamorelin has high-quality evidence, while Sermorelin has moderate-quality evidence.
Which Is Better For...
Sermorelin
More budget-friendly option with lower monthly costs
Tesamorelin
Stronger clinical evidence base to support its use
Cost Comparison
| Peptide | Monthly Cost Range | FDA Status | Manufacturer |
|---|---|---|---|
| Sermorelin | $150 - $350/mo | FDA Approved | Various research labs |
| Tesamorelin | $500 - $1,200/mo | FDA Approved | Theratechnologies |
Prices are estimated monthly costs and may vary based on pharmacy, insurance coverage, and manufacturer assistance programs. Costs for non-FDA-approved peptides reflect research compound pricing.
Frequently Asked Questions
Sermorelin works via Bioidentical analog of growth hormone releasing hormone (GHRH) that stimulates natural GH. Tesamorelin works via Synthetic GHRH analog that reduces visceral adipose tissue by stimulating growth hormone. They differ in FDA approval status, efficacy data, and cost.
Sermorelin typically costs $150 - $350/mo, while Tesamorelin costs $500 - $1,200/mo. Prices may vary by pharmacy, insurance coverage, and manufacturer programs.
Sermorelin is FDA-approved. Tesamorelin is FDA-approved. FDA approval indicates the treatment has met rigorous safety and efficacy standards.
Common side effects of Sermorelin include Injection site reactions, Flushing, Headache. Common side effects of Tesamorelin include Injection site reactions, Arthralgia, Peripheral edema. Always consult a healthcare provider about potential side effects.
Switching between peptide therapies should only be done under the guidance of a qualified healthcare provider. They can evaluate your medical history, current response, and determine the safest transition protocol.
Learn More
Sermorelin is a bioidentical synthetic version of growth hormone releasing hormone (GHRH) consisting of the first 29 amino acids of the full 44-amino acid GHRH molecule. It is FDA-approved for diagnos...
View Full Sermorelin GuideTesamorelin is an FDA-approved synthetic growth hormone releasing hormone analog specifically indicated for reducing excess abdominal fat in HIV-infected patients with lipodystrophy. Clinical trials d...
View Full Tesamorelin GuideOther Popular Comparisons
Medical Disclaimer
The information provided on this page is for educational and informational purposes only and does not constitute medical advice. This comparison between Sermorelin and Tesamorelin should not be used as a substitute for professional medical guidance. Always consult a qualified healthcare provider before starting, stopping, or modifying any peptide therapy. Clinical data cited may be from ongoing trials and is subject to change. Individual results may vary significantly. PeptideVS does not endorse, recommend, or promote the use of any specific peptide for medical treatment.