Growth Hormone
Phase 2
Evidence: Moderate

MK-677

Also known as: Ibutamoren, Nutrobal

Brand names: Ibutamoren, Nutrobal

Overview
Growth hormone optimization and muscle growth

MK-677 (Ibutamoren) is an orally-active growth hormone secretagogue that mimics the action of ghrelin. Unlike peptide injections, it is taken orally and has a long half-life allowing once-daily dosing. Clinical trials have demonstrated increases in GH and IGF-1 levels, improved bone density, and enhanced lean body mass. Despite reaching Phase 2 trials, it was never approved by the FDA.

Mechanism of Action

Oral growth hormone secretagogue that mimics ghrelin to stimulate GH and IGF-1 release

Dosage Information
ParameterDetail
AdministrationOral
Typical Dose10-25mg daily
FrequencyDaily
Side Effects
Reported adverse effects from clinical data and post-market surveillance

Common Side Effects

Increased appetite
Water retention
Fatigue
Muscle pain
Numbness or tingling

Serious Side Effects

Insulin resistance
Elevated prolactin
Potential impact on cancer risk
!Contraindications
Do not use this peptide if any of the following apply
  • Active cancer
  • Pregnancy
  • Children
  • Diabetes
Clinical Evidence

Evidence Quality

Moderate

Clinical Trial Phase

Phase 2

Cost Comparison
Estimated monthly costs compared to similar peptides
PeptideMonthly CostFDA Status
MK-677$50 - $100/mo
Phase 2
CJC-1295$35 - $70/mo
Not submitted
Ipamorelin$35 - $70/mo
Not submitted
GHRP-6$35 - $70/mo
Not submitted
Sermorelin$150 - $350/mo
FDA Approved
Compare MK-677
See how MK-677 stacks up against similar peptides

Medical Disclaimer

The information provided on this page is for educational and informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting, stopping, or modifying any peptide therapy or medication. PeptideVS does not endorse, recommend, or promote the use of any specific peptide for medical treatment. Clinical data cited may be from ongoing trials and is subject to change. Individual results may vary.