Sermorelin vs AOD-9604
A comprehensive, data-driven comparison of Sermorelin (GHRH 1-29) and AOD-9604 (Advanced Obesity Drug). Compare efficacy, side effects, costs, FDA approval status, and clinical evidence to make an informed decision.
Side-by-Side Comparison
| Property | Sermorelin GHRH 1-29, GRF 1-29 | AOD-9604 Advanced Obesity Drug, Tyr-hGH Fragment 176-191 |
|---|---|---|
| FDA Status | Withdrawn (off-label use continues) | Phase 2 (failed; reclassification pending) |
| Category | Growth Hormone | Weight Loss |
| Primary Use | Growth hormone deficiency and anti-aging | Fat loss and metabolism enhancement |
| Weight Loss % | N/A | N/A |
| Monthly Cost | $150 - $350/mo | $30 - $60/mo |
| Administration | Subcutaneous injection | Subcutaneous injection |
| Typical Dose | 200-500mcg daily before bed | 300mcg daily |
| Frequency | Daily | Daily |
| Mechanism | Bioidentical analog of growth hormone releasing hormone (GHRH) that stimulates natural GH production | Modified fragment of human growth hormone (amino acids 176-191) that stimulates lipolysis without affecting blood sugar or IGF-1 |
| Common Side Effects |
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| Serious Side Effects |
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| Evidence Quality | Moderate | Low |
| Clinical Trial Phase | N/A | Phase 2 |
Key Differences
- 1AOD-9604 is generally more affordable ($30 - $60/mo) compared to Sermorelin ($150 - $350/mo).
- 2Sermorelin has moderate-quality evidence, while AOD-9604 has low-quality evidence.
- 3They belong to different categories: Sermorelin (Growth Hormone) vs AOD-9604 (Weight Loss).
Which Is Better For...
AOD-9604
More budget-friendly option with lower monthly costs
AOD-9604
Fewer commonly reported side effects
Sermorelin
Stronger clinical evidence base to support its use
Cost Comparison
| Peptide | Monthly Cost Range | FDA Status | Manufacturer |
|---|---|---|---|
| Sermorelin | $150 - $350/mo | Withdrawn (off-label use continues) | Various research labs |
| AOD-9604 | $30 - $60/mo | Phase 2 (failed; reclassification pending) | Various research labs |
Prices are estimated monthly costs and may vary based on pharmacy, insurance coverage, and manufacturer assistance programs. Costs for non-FDA-approved peptides reflect research compound pricing.
Frequently Asked Questions
Sermorelin works via Bioidentical analog of growth hormone releasing hormone (GHRH) that stimulates natural GH. AOD-9604 works via Modified fragment of human growth hormone (amino acids 176-191) that stimulates lipolysis. They differ in FDA approval status, efficacy data, and cost.
Sermorelin typically costs $150 - $350/mo, while AOD-9604 costs $30 - $60/mo. Prices may vary by pharmacy, insurance coverage, and manufacturer programs.
Sermorelin is not FDA-approved (Withdrawn (off-label use continues)). AOD-9604 is not FDA-approved (Phase 2 (failed; reclassification pending)). FDA approval indicates the treatment has met rigorous safety and efficacy standards.
Common side effects of Sermorelin include Injection site reactions, Flushing, Headache. Common side effects of AOD-9604 include Injection site reactions, Headache, Chest tightness (rare). Always consult a healthcare provider about potential side effects.
Switching between peptide therapies should only be done under the guidance of a qualified healthcare provider. They can evaluate your medical history, current response, and determine the safest transition protocol.
Learn More
Sermorelin is a bioidentical synthetic version of growth hormone releasing hormone (GHRH) consisting of the first 29 amino acids of the full 44-amino acid GHRH molecule. It was previously FDA-approved...
View Full Sermorelin GuideAOD-9604 is a modified peptide fragment of the C-terminus of human growth hormone (amino acids 176-191). It was designed to retain the fat-burning properties of HGH while avoiding effects on blood sug...
View Full AOD-9604 GuideOther Popular Comparisons
Medical Disclaimer
The information provided on this page is for educational and informational purposes only and does not constitute medical advice. This comparison between Sermorelin and AOD-9604 should not be used as a substitute for professional medical guidance. Always consult a qualified healthcare provider before starting, stopping, or modifying any peptide therapy. Clinical data cited may be from ongoing trials and is subject to change. Individual results may vary significantly. PeptideVS does not endorse, recommend, or promote the use of any specific peptide for medical treatment.