Tirzepatide
Also known as: Mounjaro, Zepbound
Brand names: Mounjaro, Zepbound
Tirzepatide is a dual-action peptide approved by the FDA as Mounjaro for type 2 diabetes and Zepbound for weight management. In December 2024, Zepbound became the first and only medication approved for moderate-to-severe obstructive sleep apnea (OSA) in adults with obesity. It is the first medication to target both GIP and GLP-1 receptors simultaneously. In the SURMOUNT-1 trial, participants achieved an average weight loss of 22.5% over 72 weeks.
Dual GIP/GLP-1 receptor agonist that enhances insulin secretion, reduces glucagon, slows gastric emptying, and decreases appetite
| Parameter | Detail |
|---|---|
| Administration | Subcutaneous injection |
| Typical Dose | 15mg weekly (max dose) |
| Frequency | Weekly |
Common Side Effects
Serious Side Effects
- Personal or family history of medullary thyroid carcinoma
- Multiple endocrine neoplasia syndrome type 2
- Pregnancy
Evidence Quality
Clinical Trial Phase
Approved (post-market)
Average Weight Loss in Trials
22.5%
| Peptide | Monthly Cost | FDA Status |
|---|---|---|
| Tirzepatide | $1100 - $1100/mo | FDA Approved |
| Semaglutide | $1000 - $1400/mo | FDA Approved |
| Retatrutide | $1200 - $1500/mo | Phase 3 (NDA expected late 2026) |
| AOD-9604 | $30 - $60/mo | Phase 2 (failed; reclassification pending) |
Where to get Tirzepatide
Prescription telehealth partners - see pricing and eligibility.
PeptideVS may earn a commission from providers listed below. Our editorial data is independent - see our disclosure for details.
Henry Meds
Sponsored
Compounded GLP-1 therapy with flat monthly pricing and no insurance hassle.
- Flat monthly price, no insurance required
- Compounded semaglutide and tirzepatide
- Licensed providers in 50 states
We may earn a commission when you sign up.
Mochi Health
Sponsored
Obesity-medicine-trained clinicians and a care team built around women.
- Obesity-medicine-trained MDs and RDs
- Compounded and brand-name GLP-1 options
- Insurance-aware pricing and savings tools
We may earn a commission when you sign up.
Found Health
Sponsored
Weight-care program combining GLP-1s with behavior coaching and nutritionists.
- Whole-person program, not just a prescription
- Insurance-first with cash-pay fallback
- Nutrition and habit coaching included
We may earn a commission when you sign up.
Ro Body
Sponsored
Brand-name Wegovy and Zepbound plus compounded options, handled end to end.
- Brand-name and compounded GLP-1 paths
- Insurance navigation built into intake
- Nationwide telehealth with ongoing check-ins
We may earn a commission when you sign up.
Hers Weight
Sponsored
GLP-1 injections paired with behavior coaching for long-term weight care.
- Compounded GLP-1 with licensed providers
- Coaching and habit support in-app
- Transparent monthly pricing
We may earn a commission when you sign up.
PlushCare
Sponsored
Primary-care telehealth with broad Rx coverage and same-day appointments.
- Broad primary-care scope, not GLP-1-only
- Same-day video visits in all 50 states
- Works with insurance for most plans
We may earn a commission when you sign up.
Medical Disclaimer
The information provided on this page is for educational and informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting, stopping, or modifying any peptide therapy or medication. PeptideVS does not endorse, recommend, or promote the use of any specific peptide for medical treatment. Clinical data cited may be from ongoing trials and is subject to change. Individual results may vary.