Semaglutide
Also known as: Ozempic, Wegovy
Brand names: Ozempic, Wegovy, Rybelsus, Oral Wegovy
Semaglutide is an FDA-approved GLP-1 receptor agonist marketed as Ozempic for type 2 diabetes and Wegovy for chronic weight management. In August 2025, it received accelerated approval for MASH (metabolic-associated steatohepatitis) with liver fibrosis. An oral formulation (Oral Wegovy) was approved in December 2025, launching in January 2026. Clinical trials demonstrated an average weight loss of 15% over 68 weeks with injectable Wegovy, and 16.6% with oral Wegovy. The medication works by mimicking GLP-1, a natural hormone that regulates blood sugar and appetite.
GLP-1 receptor agonist that mimics incretin hormone to increase insulin secretion, slow gastric emptying, and reduce appetite
| Parameter | Detail |
|---|---|
| Administration | Subcutaneous injection |
| Typical Dose | 2.4mg weekly (Wegovy dose) |
| Frequency | Weekly |
Common Side Effects
Serious Side Effects
- Personal or family history of medullary thyroid carcinoma
- Multiple endocrine neoplasia syndrome type 2
- Pregnancy
Evidence Quality
Clinical Trial Phase
Approved (post-market)
Average Weight Loss in Trials
15%
| Peptide | Monthly Cost | FDA Status |
|---|---|---|
| Semaglutide | $1000 - $1400/mo | FDA Approved |
| Tirzepatide | $1100 - $1100/mo | FDA Approved |
| Retatrutide | $1200 - $1500/mo | Phase 3 (NDA expected late 2026) |
| AOD-9604 | $30 - $60/mo | Phase 2 (failed; reclassification pending) |
Where to get Semaglutide
Prescription telehealth partners - see pricing and eligibility.
PeptideVS may earn a commission from providers listed below. Our editorial data is independent - see our disclosure for details.
Henry Meds
Sponsored
Compounded GLP-1 therapy with flat monthly pricing and no insurance hassle.
- Flat monthly price, no insurance required
- Compounded semaglutide and tirzepatide
- Licensed providers in 50 states
We may earn a commission when you sign up.
Mochi Health
Sponsored
Obesity-medicine-trained clinicians and a care team built around women.
- Obesity-medicine-trained MDs and RDs
- Compounded and brand-name GLP-1 options
- Insurance-aware pricing and savings tools
We may earn a commission when you sign up.
Found Health
Sponsored
Weight-care program combining GLP-1s with behavior coaching and nutritionists.
- Whole-person program, not just a prescription
- Insurance-first with cash-pay fallback
- Nutrition and habit coaching included
We may earn a commission when you sign up.
Ro Body
Sponsored
Brand-name Wegovy and Zepbound plus compounded options, handled end to end.
- Brand-name and compounded GLP-1 paths
- Insurance navigation built into intake
- Nationwide telehealth with ongoing check-ins
We may earn a commission when you sign up.
Hers Weight
Sponsored
GLP-1 injections paired with behavior coaching for long-term weight care.
- Compounded GLP-1 with licensed providers
- Coaching and habit support in-app
- Transparent monthly pricing
We may earn a commission when you sign up.
PlushCare
Sponsored
Primary-care telehealth with broad Rx coverage and same-day appointments.
- Broad primary-care scope, not GLP-1-only
- Same-day video visits in all 50 states
- Works with insurance for most plans
We may earn a commission when you sign up.
Medical Disclaimer
The information provided on this page is for educational and informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting, stopping, or modifying any peptide therapy or medication. PeptideVS does not endorse, recommend, or promote the use of any specific peptide for medical treatment. Clinical data cited may be from ongoing trials and is subject to change. Individual results may vary.