Cognitive Enhancement
Not submitted
Evidence: Moderate

Semax

Overview
Cognitive enhancement and neuroprotection

Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) developed in Russia. It has been shown to increase brain-derived neurotrophic factor (BDNF), improve cerebral blood flow, and provide neuroprotective effects. Used in Russia for treating cognitive impairments and stroke recovery.

Mechanism of Action

Synthetic ACTH analog that enhances BDNF production, improves cerebral circulation, and protects neurons

Dosage Information
ParameterDetail
AdministrationNasal spray
Typical Dose2-3 drops per nostril 2-3x daily
FrequencyDaily
Side Effects
Reported adverse effects from clinical data and post-market surveillance

Common Side Effects

Nasal irritation
Mild stimulation
Headache
Anxiety (at high doses)

Serious Side Effects

Unknown long-term effects
Potential sleep disturbances
!Contraindications
Do not use this peptide if any of the following apply
  • Pregnancy
  • Breastfeeding
  • Severe anxiety disorders
  • Children
Clinical Evidence

Evidence Quality

Moderate

Clinical Trial Phase

Preclinical / Not submitted

Cost Comparison
Estimated monthly costs compared to similar peptides
PeptideMonthly CostFDA Status
Semax$45 - $90/mo
Not submitted
Selank$40 - $80/mo
Not submitted
Compare Semax
See how Semax stacks up against similar peptides

Medical Disclaimer

The information provided on this page is for educational and informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting, stopping, or modifying any peptide therapy or medication. PeptideVS does not endorse, recommend, or promote the use of any specific peptide for medical treatment. Clinical data cited may be from ongoing trials and is subject to change. Individual results may vary.